Couples undergoing what is a relatively new procedure are naturally concerned to know about all of the risks involved. Certain risks are common to in vitro fertilisation and ICSI; namely, the chance of developing Ovarian HyperStimulation Syndrome and the chance of multiple pregnancy. However, while there have been nearly two million babies born following standard in vitro fertilisation treatment, the number of babies born following ICSI is probably a few hundred thousand. From assessment of these babies following ICSI, the following represents the current state of our knowledge about the …

In certain cases, manipulation of the embryo can enhance implantation and subsequent pregnancy. Common practice is to use acidified Tyrode’s solution (pH 2.35) to thin the zona pellucida. An increase in implantation from 18 % to 25 % is achievable for oocytes with poor prognosis with this intervention, refeffed to as assisted hatching. Assisted hatching is not applicable only for male factor infertility, in fact, it is a treatment for specific defects in embryo development or oocyte abnormalities. However, it is a micromanipulation technique that is routinely performed during IVF …

The bypass of natural barriers to fertilization, possible genetic defects in men with severe male infertility, and the use of severely abnormal sperm for intracytoplasmic sperm injection has engendered concern over the impact of ICSI on the genetic complement of the offspring . Previous studies have suggested no increase in birth defect rates when IV-F alone was used to induce conception. Van Steirteghem reported no increase in the congenital malformation rate in their center after ICSI when compared with the general population. Of 877 children born after ICSI procedures, 23 …

Risks of IVF-ICSI include general risks of IVF as well as the specific risks related to the micromanipulation procedure of ICSI. One of the most significant risks associated with stimulation of the ovaries is the ovarian hyperstimulation syndrome (OHSS). This can manifest as massive ovarian enlargement, peritoneal irritation due to follicular rupture or hemorrhage, ovarian torsion, ascites, pleural effusion, oliguria, electrolyte imbalance, hypercoagulability3l I and sometimes death36 . The syndrome occurs in a moderate form for 3-4% percent of initiated cycles, and in a severe form for 0. 1-0.2 % …

One of the largest series reporting results using IVF/ICSI was from Van Steirteghem et al. at The Brussels Free University in Brussels, Belgium. In their preliminary report on 150 couples who underwent 150 consecutive treatment cycles, 1409 oocytes were injected and 830 were successfully fertilized for a fertilization rate of 59 percent. A total clinical pregnancy rate of 35 percent was achieved. The fertilization rate in this study was not influenced by the standard semen characteristics of concentration, motility, and strict criteria morphology. In another largest case serie on ICSI …

Until recently, the clinical application of direct injection of a single sperm into the cytoplasm of an oocyte during IVF was not shown to be feasible. The demonstration of fertilization and live births by Palermo et al. in 1993 was the first successful application of ICSI. Since that time, ICSI has been performed extensively in multiple centers to treat patients with severe male factor infertility. To date, the success of ICSI procedures has been related to several factors: (1) the viability of the spermatozoon, (2) the quality of the oocyte, …

ICSI stands for Intro Cytoplasmic Sperm Injection. The whole technique was developed by researches of Brussels University and a science institution in St. Louis, US. The amazing thing about ICSI procedure is that men who were considered ultimately unable to fertilize have succeeded in it and the procedure implication worldwide has already resulted in more than 10,000 babies and perfectly physically, genetically and mentally babies they are. You or your spouse might be the one for ICSI procedure if you are closely familiar with one of the following cases.
The …

Intra-cytoplasmic sperm injection (ICSI) is a relatively new but well-established procedure first performed in 1992. The procedure was developed to help male factor infertility. The procedure involves injecting a single sperm into the cytoplasm of each egg using a fine glass needle. The first ICSI baby was reported in 1992. The ICSI has largely replaced the two previously developed procedures, PZD (partial zona dissection) and SUZI (subzonal insemination) because it achieves much higher fertilization rates.
The injection of immature sperm (spermatid) into the egg is not allowed in the UK because …

Intracytoplasmic Sperm Injection (ICSI) is performed as part of an IVF procedure to treat male factor abnormalities. After egg retrieval, using a glass needle, a single sperm is selected by and injected into the egg. This often enhances fertilization to help couples conceive when the man has low sperm concentration, motility, or abnormal shapes. The Follas Center of Reproductive Medicine, our adjacent office-based facility, has state-of-the-art equipment to offer this option to our patients undergoing IVF.
Intracytoplasmic sperm injection, or ICSI, is a form of micro-assisted fertilization where the nucleus (genetic …

Any IVF (in vitro fertilization) treatment procedure carries risks. ICSI (intra-cytoplasmic sperm injection), being a very delicate and difficult IVF procedure, does carry an even higher risk of failure. Normally during an IVF treatment programme the males sperm are subjected to rigorous procedures to establish their maturity and suitability for the procedure. In an ICSI procedure, because the number of viable sperm available can be so low they are not subjected to a rigorous programme of testing. The risk of an abnormal sperm being injected into the ovum is, therefore, …